Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization

نویسندگان

  • Marta Imamura
  • Fernando Ezquerro
  • Fábio Marcon Alfieri
  • Lucy Vilas Boas
  • Tania Regina Tozetto-Mendoza
  • Janini Chen
  • Levent Özçakar
  • Lars Arendt-Nielsen
  • Linamara Rizzo Battistella
چکیده

Osteoarthritis (OA) is the most common joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis. Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients' functional capacity and pressure pain threshold (PPT) values.

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عنوان ژورنال:

دوره 2015  شماره 

صفحات  -

تاریخ انتشار 2015